Intramuscular cimeti- dine and ranitidine as prophylaxis against gastric aspiration
نویسندگان
چکیده
Preoperative cimetidine 300 mg or ranitidh~e in 50 and 100 mg doses were administered intramuscularly to 120 patients in a randomized double-blind study. The volume and pH of gastric aspirate samples obtained after tracheal intubation and before extabation were measured. The pH of gastric aspirate was higher Jbllowing ranitidine 100 mg than ranitidine 50 mg or cimetidine 300 mg at both intubation and extubation (p = 0.006). In addition, fewer patients tended to be "at risk" of pulmonary aspiration syndrome (pH <2.5) after ranitidine lOOmg than ranitidine 50 mg or cimetidine 300 mg. Preoperative intramuscular ranitidine 100 mg was found to be suitable figr use in protection against gastric aspiration syndrome.
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